ADMET polymerization of bio-based biphenyl compounds

Highly Branched Bio-Based Unsaturated Polyesters by Enzymatic Polymerization

A one-pot, enzyme-catalyzed bulk polymerization method for direct production of highly branched polyesters has been developed as an alternative to currently used industrial procedures. Bio-based feed components in the form of glycerol, pentaerythritol, azelaic acid, and tall oil fatty acid (TOFA) were polymerized using an immobilized Candida antarctica lipase B (CALB) and the potential for an e...

Phosphorylation of bio-based compounds: the state of the art

Utility of protein structures in overcoming ADMET-related issues of drug-like compounds.

The number of solved X-ray structures of proteins relevant for ADMET processes of drug molecules has increased remarkably over recent years. In principle, this development offers the possibility to complement the quantitative structure-property relationship (QSPR)-dominated repertoire of in silico ADMET methods with protein-structure-based approaches. However, the complex nature and the weak no...

Synthesis of (Bio)degradable Polymers via Thiol-ene Click Polymerization

Towards the development of (bio)degradable polymers with medical relevance a non-radical thiolene synthesis route is investigated. In this work, step growth polymerization based on Michael addition click reactions is presented. Homotelechelic RAFT polymers were conjugated leading to polymers with molar weight distribution typical for a step growth polymerization, tailing up to 100 000 g∙mol-1 i...

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...